U.S. Route 395 Business may refer to: U.S. Route 395 Business (Riverside, California) U.S. Route 395 Business (Colton–San Bernardino, California) U.S. Route 395 Business (Ridgecrest, California) U.S. Route 395 Business (Cartago–Olancha, California), running through Cartago and Olancha, California U.S. Route 395 Business (Carson City, Nevada) U.S. Route 395 Business (Reno, Nevada)