Manlio is a given name. Notable people with the given name include:
Manlio Argueta (born 1935), Salvadoran writer, critic and novelist Manlio Bacigalupo (1908–1977), Italian football player and manager Manlio De Angelis (1935–2017), Italian actor and voice actor Manlio Di Stefano (born 1981), Italian politician Manlio Fabio Beltrones (born 1952), Mexican economist and politician Manlio Brosio (1897–1980), Italian lawyer, diplomat and politician Manlio Graziano, Italian geopolitician Manlio Legat (1889–1915), Italian track and field athlete Manlio Martinelli (1884–1974), Italian painter Manlio Morgagni (1879–1943), Italian journalist and politician Manlio Pastorini (1879–1942), Italian gymnast Manlio Rho (1901–1957), Italian painter Manlio Rocchetti (1943–2017), Italian makeup artist Manlio Di Rosa (1914–1989), Italian fencer Manlio Sgalambro (1924–2014), Italian philosopher and writer Manlio Simonetti (1926–2017), Italian biblical scholar Manlio Vinciguerra (born 1976), Italian scientist Manlio Vitale (born 1949), Italian criminal