Upson is a surname. Notable people with the surname include:
Arthur Upson, American poet Charles Upson, U.S. Representative from Michigan Christopher C. Upson, U.S. Representative from Texas Devonte Upson (born 1993), American basketball player in the Israeli Basketball Premier League Donna Upson, Canadian white supremacist Jill Upson, American politician Matthew Upson, English football player Maxwell Upson, trustee of Cornell University Nicola Upson (born 1970), British novelist Ralph Hazlett Upson, American balloonist Stephen Upson, American politician and lawyer William Hazlett Upson, American author