Trapani is a surname. Notable people with the surname include:
Enzo Trapani (1922–1989), Italian screenwriter, set designer, television producer/director and film director Francesco Trapani (1957–2025), Italian chief executive Gina Trapani (born 1975), American tech blogger, web developer and writer Joe Trapani (born 1988), American basketball player Sal Trapani (1927–1999), American comic-book artist