Joe O'Brien may refer to:
Joe O'Brien (American football) (born 1972), American football player and coach Joe O'Brien (basketball) (born 1955), American basketball coach Joe O'Brien (cyclist) (fl. 1959–1960), Irish cyclist Joe O'Brien (19th-century footballer), played for Manchester City and Walsall Town Swifts, see List of Manchester City F.C. players (1–24 appearances) Joe O'Brien (footballer) (1875–?), Scottish footballer Joe O'Brien (harness racing) (1917–1984), American driver, trainer and owner Joe O'Brien (politician), Irish Green Party politician and TD in the 32nd Dáil
See also Joe O'Brien Field, Elizabethton, Tennessee Joseph O'Brien (disambiguation)