Wickwire is a surname. Notable people with the surname include:
Chester Wickwire (1913–2008), American civil rights activist Harry H. Wickwire (1868–1922), Canadian lawyer and politician Jim Wickwire (born 1940), American mountain climber John Wickwire (1899–1994), Canadian politician Nancy Wickwire (1925–1974), American actress
See also Wickwire Hill, a summit in New York