HSD may refer to:

School districts Hackett School District, in Arkansas, United States Harrison School District (disambiguation) Hazelwood School District, in Missouri, United States Hillsboro School District in Oregon, United States

Other uses Hamstead railway station, England Hardanger Sunnhordlandske Dampskipsselskap, a former Norwegian transport company Heliophysics Science Division, a branch of the United States National Atmospheric and Space Administration High School Diploma Historical Society of Delaware Hollywood Stunt Driver, a live show at Warner Bros. Movie World Homeland Security Department Hybrid Synergy Drive, a set of hybrid car technologies Hydroxysteroid dehydrogenase Hypoactive sexual desire, a disorder characterized as a lack or absence of sexual fantasies and desire for sexual activity Hypermobility spectrum disorder Tukey's honest significant difference test