Papo is a masculine given name and nickname. It is also used as a surname. It may refer to:
Surname Eliezer Papo (1785–1828), rabbi and writer in the Ottoman Empire Hope Papo, South African politician Izidor Papo (1913–1996), Austro-Hungarian surgeon, officer, military medical chief and academician Roza Papo (1914–1984), Yugoslav physician and general
Given name Papo Colo (born 1946), Puerto Rican performance artist, painter, writer and curator Papo Lucca (born 1946), Puerto Rican musician
Nickname Alfredo Alejandro Carrión (born 1948), Puerto Rican politician Petrus Compton, 21st century Saint Lucian politician Jose Garcia Cosme (1957–2019), better known as Papo Cachete, Puerto Rican convicted drug dealer Juan "Papo" Franceschi (c. 1946–1990), Puerto Rican sprinter Papo Román (born 1957), Puerto Rican musician