Chkhikvadze ( or ) is a surname of Georgian origin. Notable people with this name include:
Irakli Chkhikvadze (b. 1987), Georgian rugby player Keti Chkhikvadze (), Georgian fashion designer (1883–1920), Georgian poet (1903–1940), Soviet and Georgian writer Ramaz Chkhikvadze () (1928–2011), Georgian actor (b. 1947), Georgian writer (1911–2006), Russian jurist (b. 1950), former Russian ambassador to Chile (1940–2019), Soviet herpetologist and paleontologist