The 1968 Penn Quakers football team represented the University of Pennsylvania as a member of the Ivy League during the 1968 NCAA University Division football season. Led by fourth-year head coach Bob Odell, the Quakers compiled an overall record of 7–2 with a mark of 5–2 in conference play, placing third in the Ivy League. Penn played home games at Franklin Field on the university's campus in Philadelphia.

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