LES or Les may refer to:
People Les (given name) Les (surname) L.E.S. (producer), hip hop producer
Space flight Launch Entry Suit, worn by Space Shuttle crews Launch escape system, for spacecraft emergencies Lincoln Experimental Satellite series, 1960s and 1970s
Biology and medicine Lazy eye syndrome, or amblyopia, a disorder in the human optic nerve The Liverpool epidemic strain of Pseudomonas aeruginosa Lower esophageal sphincter Lupus erythematosus systemicus
Places The Lower East Side neighborhood of Manhattan, New York City Les, Catalonia, a municipality in Spain Leş, a village in Nojorid Commune, Bihor County, Romania Les, the Hungarian name for Leșu Commune, Bistriţa-Năsăud County, Romania Les, a village in Tejakula district, Buleleng regency, Bali, Indonesia Lesotho, IOC and UNDP country code Lès, a word featuring in many French placenames
Transport Leigh-on-Sea railway station, National Rail station code Leytonstone tube station, London Underground station code
Other uses "L.E.S.", a song by Childish Gambino from Camp (album) Lake-effect snow Large eddy simulation in fluid dynamics Law Enforcement Sensitive, a US security classification Leave and Earnings Statement, of US military Les (Vietnam), a Vietnamese term for lesbians Les+ Magazine, a Chinese LGBT magazine Licensing Executives Society International, a US intellectual property organization Life Extension Society, a cryonics organization Lifetime Entertainment Services, a US company Lilliput Edison screw, a 5mm light bulb socket Louisiana Energy Services, which operates the National Enrichment Facility A Slang term for Lesbian