Petrucci is an Italian surname. Notable people with the surname include:
15th–19th centuries Alessandro Petrucci (died 1628), Italian Roman Catholic Archbishop of Siena and Bishop of Massa Marittima Alfonso Petrucci (c. 1490–1517), Italian Roman Catholic cardinal Antonello Petrucci, also known as Antonello d'Aversa (died 1487), Italian Baron and secretary to King Ferdinand I of Naples Borghese Petrucci (1512–1516), Italian politician, ruler of Siena Domenico Petrucci (died 1598), Italian Roman Catholic Bishop of Bisignano and later Bishop of Strongoli Giovanni Alfonso Petrucci (1650–1688), Roman Catholic Bishop of Belcastro Ottaviano Petrucci (1466–1539) Italian printer, producer of sheet music Pandolfo Petrucci (1452–1512) ruler of Siena Pier Matteo Petrucci, C.O. (1636–1701), Italian Roman Catholic cardinal Raffaello Petrucci (1472–1522), cardinal, ruler of Siena
20th century A. J. Petrucci, American professional wrestler Cinzia Petrucci (born 1955) Italian shot putter Danilo Petrucci (born 1991) Italian motorcyclist Davide Petrucci (born 1991) Italian football (soccer) player Gianni Petrucci (born 1945) Italian sports director Giovanna Petrucci (born 1998), Brazilian athlete John Petrucci (born 1967) American rock guitarist Loretto Petrucci (1929–2016) Italian cyclist Luigi Petrucci (born 1956) Italian actor Mario Petrucci (born 1958), English poet, literary translator, educator and broadcaster Roxy Petrucci (born 1960) American drummer