Guilfoil is a surname. Notable people with the surname include:

Dwight D. Guilfoil Jr. (1922–1989), American businessman Kelly (née Guilfoil) Craft (born 1962), United States Ambassador to the United Nations and United States Ambassador to Canada O. D. Guilfoil (1863–1955), American politician Tyler Guilfoil (born 2000), American baseball player

See also Guilfoile