SN-22, also known as 3-(1-methyl-4-piperidinyl)indole, is a serotonin receptor modulator of the piperidinylindole group related to the psychedelic drug dimethyltryptamine (DMT). Though it is not technically a tryptamine itself, SN-22 can be regarded as a constrained analogue of DMT.
The drug shows affinity for the serotonin 5-HT1A and 5-HT2A receptors (Ki = 146–514nM and 19–67nM, respectively). A deuterated isotopologue of SN-22 is known to be a serotonin 5-HT2A receptor agonist, albeit with lower potency than DMT.
The chemical synthesis of SN-22 has been described. Analogues of SN-22 include MTHPI, RU-24969 (5-MeO-THPI), RU-28253, and MPMI, among others. Derivatives include BRL-54443 (5-hydroxy-SN-22), LY-334370, naratriptan, and sertindole. Many other derivatives of SN-22 are also known, most of which are ligands for serotonin 5-HT1A, 5-HT2A, or 5-HT6 receptors, dopamine D2 receptors, or the serotonin transporter (SERT). Deuterated derivatives of SN-22 have been described as well. SN-22, along with MTHPI, shows some resemblance to MPTP in terms of chemical structure.
SN-22 was first described in the scientific literature by Ethan Will Taylor and colleagues by 1988.
See also Piperidinylindole Cyclized tryptamine Substituted tryptamine § Related compounds
References
External links SN-22 - Isomer Design