The Second Andrews ministry was the 70th ministry of the Government of Victoria. The Labor government, led by Premier Daniel Andrews and Deputy Premier James Merlino, was officially sworn in on 29 November 2018, following the party's second consecutive victory at the 2018 state election, which was held on 24 November 2018.

At the time of its formation, the ministry consisted of 22 ministers, eleven of whom were women, making it the first cabinet in Victoria's history to reach gender parity. To accommodate this change Philip Dalidakis was removed from his cabinet position. However, his work as a minister was praised by Andrews. Following the resignation of Gavin Jennings and the appointment of Ros Spence on 23 March 2020, the Cabinet became majority female.

The Second Andrews ministry succeeded the First Andrews ministry, and was succeeded by the Third Andrews ministry.

Second Andrews ministry, 2018–2022 June 2022–October 2022 A cabinet reshuffle was undertaken in June 2022 after five cabinet ministers had announced their upcoming retirement at the November state election: James Merlino, Martin Foley, Lisa Neville, Martin Pakula and Richard Wynne.

Lizzie Blandthorn, Colin Brooks, Steve Dimopoulos, Sonya Kilkenny and Harriet Shing were appointed to the ministry to replace the retiring ministers. The rearranged ministry was sworn in on 27 June. Kilkenny was sworn in a week later on 4 July as she had contracted COVID-19 and had to isolate prior to the original swearing-in ceremony.

Two new ministerial roles were also created to oversee the 2026 Commonwealth Games to be held in the state.

MinisterPortfolioDaniel Andrews, MP Premier Jacinta Allan, MP Deputy Premier Minister for Transport Infrastructure Minister for the Suburban Rail Loop Minister for Commonwealth Games Delivery Jaclyn Symes, MLC Leader of the Government in the Legislative Council Attorney-General Minister for Emergency Services Gayle Tierney, MLC Deputy Leader of the Government in the Legislative Council Minister for Training and Skills Minister for Higher Education Minister for Agriculture Tim Pallas, MP Treasurer Minister for Industrial Relations Minister for Economic Development Minister for Trade Lizzie Blandthorn, MP Leader of the House Minister for Planning Colin Brooks, MP Minister for Child Protection and Family Services Minister for Disability, Ageing and Carers Anthony Carbines, MP Minister for Police Minister for Crime Prevention Minister for Racing Ben Carroll, MP Minister for Industry Support and Recovery Minister for Business Precincts Minister for Public Transport Minister for Roads and Road SafetyLily D'Ambrosio, MP Minister for Energy Minister for Environment and Climate Action Minister for Solar Homes Steve Dimopoulos, MP Minister For Tourism, Sport And Major Events Minister For Creative Industries Melissa Horne, MP Minister for Consumer Affairs, Gaming and Liquor Regulation Minister for Ports and Freight Minister for Local Government Minister for Suburban Development Natalie Hutchins, MP Minister for Education Minister for Women Sonya Kilkenny, MP Minister for Corrections (from 4 July 2022) Minister for Youth Justice (Victoria) (from 4 July 2022) Minister for Victim Support (from 4 July 2022) Minister for Fishing and Boating (from 4 July 2022) Shaun Leane, MLC Minister for Commonwealth Games Legacy Minister for Veterans Danny Pearson, MP Minister for Housing Assistant Treasurer Minister for Government Services Minister for Regulatory Reform Jaala Pulford, MLC Minister for Employment Minister for Innovation, Medical Research and the Digital Economy Minister for Resources Minister for Small Business Harriet Shing, MLC Minister for Water Minister for Regional Development Minister for Equality Ros Spence, MP Minister for Prevention of Family Violence Minister for Multicultural Affairs Minister for Community Sport Minister for Youth Ingrid Stitt, MLC Minister for Early Childhood and Pre-Prep Minister for Workplace Safety Mary-Anne Thomas, MP Minister for Health Minister for Ambulance ServicesGabrielle Williams, MP Minister for Mental Health Minister for Treaty And First Peoples

June 2020–June 2022 On 15 June 2020, Adem Somyurek was dismissed from the ministry due to alleged misconduct, with Robin Scott and Marlene Kairouz also resigning the next day. A reshuffle took place on 22 June 2020, bringing Shaun Leane, Danny Pearson and Natalie Hutchins into cabinet and reassigning several portfolios. Hutchins was previously a minister in the First Andrews Ministry.

On 26 September 2020, health minister Jenny Mikakos resigned as minister, following Premier Daniel Andrews stating in the board of inquiry into the hotel quarantine program that he regarded Mikakos "accountable" for the program. Minister for Mental Health Martin Foley was sworn in as the new health and ambulance services minister later that day. A further reshuffle three days later on 29 September 2020 added Ingrid Stitt into the cabinet and the reassignment of some portfolios.

On 16 December 2020, Jill Hennessy announced she would step down from the role of Attorney-General effective immediately to spend more time with her family but would stay in Parliament and recontest her seat at the 2022 election. She was replaced as Attorney-General by Jaclyn Symes. Mary-Anne Thomas was added to the cabinet and was appointed Minister for Regional Development and Minister for Agriculture.

In February 2021, Lisa Neville was admitted to hospital and was forced to take leave due to Crohn's disease. She returned to work in August 2021. The nature of her emergency services portfolio required regular travel to remote parts of the state at short notice, which was unsuitable for her medical condition. Therefore, Neville relinquished the portfolio to Attorney-General Jaclyn Symes. Symes relinquished her resources portfolio to Jaala Pulford.

On 11 October 2021, Luke Donnellan resigned as minister, following the first day of the IBAC investigation Operation Watts. Donnellan claims he never misused public funds but had previously breached party rules as Minister. He was replaced by Anthony Carbines on 6 December 2021.

MinisterPortfolioDaniel Andrews, MP Premier James Merlino, MP Deputy Premier Minister for Education Minister for Mental Health (from 29 September 2020) Minister for Disability, Ageing and Carers (acting, from 11 October 2021 until 6 December 2021) Tim Pallas, MP Treasurer Minister for Economic Development Minister for Industrial Relations Jacinta Allan, MP Minister for Transport Infrastructure Minister for the Suburban Rail LoopMartin Foley, MP Minister for Health (from 26 September 2020) Minister for Ambulance Services (from 26 September 2020) Minister for Equality Minister for Mental Health (until 29 September 2020) Minister for Creative Industries (until 29 September 2020)Richard Wynne, MP Minister for Planning Minister for Housing Minister for Child Protection (acting, from 11 October 2021 until 6 December 2021) Jaclyn Symes, MLC Leader of the Government in the Legislative Council Attorney-General (from 22 December 2020) Minister for Emergency Services (from 23 August 2021) Minister for Resources (until 23 August 2021) Minister for Regional Development (until 22 December 2020) Minister for Agriculture (until 22 December 2020) Martin Pakula, MP Minister for Industry Support and Recovery Minister for Trade Minister for Business Precincts Minister for Tourism, Sport and Major Events Minister for Racing Lisa Neville, MP Minister for Police (from 23 August 2021) Minister for Water Minister for Police and Emergency Services (until 23 August 2021)Gabrielle Williams, MP Minister for Women Minister for Prevention of Family Violence Minister for Aboriginal AffairsLily D'Ambrosio, MP Minister for Energy, Environment and Climate Change Minister for Solar Homes Jaala Pulford, MLC Minister for Employment Minister for Innovation, Medical Research and the Digital Economy Minister for Small Business Minister for Resources (since 23 August 2021) Mary-Anne Thomas, MP Minister for Regional Development (from 22 December 2020) Minister for Agriculture (from 22 December 2020) Ben Carroll, MP Minister for Public Transport Minister for Roads and Road Safety Gayle Tierney, MLC Deputy Leader of the Government in the Legislative Council (from 29 September 2020) Minister for Training and Skills Minister for Higher Education Melissa Horne, MP Minister for Ports and Freight Minister for Consumer Affairs, Gaming and Liquor Regulation Minister for Fishing and Boating Ros Spence, MP Minister for Multicultural Affairs Minister for Community Sport Minister for Youth Shaun Leane, MLC Minister for Suburban Development Minister for Local Government Minister for Veterans Natalie Hutchins, MP Minister for Crime Prevention Minister for Corrections Minister for Youth Justice (Victoria) Minister for Victim Support Danny Pearson, MP Assistant Treasurer Minister for Regulatory Reform Minister for Government Services Minister for Creative Industries (from 29 September 2020) Ingrid Stitt, MLC Minister for Workplace Safety (from 29 September 2020) Minister for Early Childhood (from 29 September 2020) Anthony Carbines, MP Minister for Child Protection and Family Services (from 6 December 2021) Minister for Disability, Ageing and Carers (from 6 December 2021) Former Ministers Luke Donnellan, MP Minister for Child Protection (until 11 October 2021) Minister for Disability, Ageing and Carers (until 11 October 2021) Jill Hennessy, MP Attorney-General (until 16 December 2020) Minister for Workplace Safety (until 29 September 2020)Jenny Mikakos, MLC Deputy Leader of the Government in the Legislative Council (23 March to 26 September 2020) Minister for Health (until 26 September 2020) Minister for Ambulance Services (until 26 September 2020)

November 2018–June 2020 The first arrangement of the Second Andrews ministry was sworn in on 29 November 2018.

Gavin Jennings resigned from Parliament and the ministry on 23 March 2020. He was replaced in cabinet by Ros Spence.

MinisterPortfolioDaniel Andrews, MP Premier James Merlino, MP Deputy Premier Minister for Education Tim Pallas, MP Treasurer Minister for Economic Development Minister for Industrial Relations Jill Hennessy, MP Attorney-General Minister for Workplace Safety Jacinta Allan, MP Minister for Transport Infrastructure Minister for Priority Precincts (from 23 March 2020)Jenny Mikakos, MLC Deputy Leader of the Government in the Legislative Council (from 23 March 2020) Minister for Health Minister for Ambulance ServicesMartin Foley, MP Minister for Mental Health Minister for Equality Minister for Creative IndustriesRichard Wynne, MP Minister for Planning Minister for Housing Minister for Multicultural Affairs (until 23 March 2020) Jaclyn Symes, MLC Leader of the Government in the Legislative Council (from 23 March 2020) Minister for Regional Development Minister for Agriculture Minister for Resources Deputy Leader of the Government in the Legislative Council (until 23 March 2020) Martin Pakula, MP Minister for Jobs, Innovation and Trade Minister for Tourism, Sport and Major Events Minister for Racing Lisa Neville, MP Minister for Police and Emergency Services Minister for WaterRobin Scott, MP Assistant Treasurer Minister for VeteransGabrielle Williams, MP Minister for Women Minister for Prevention of Family Violence Minister for Aboriginal Affairs (from 23 March 2020) Minister for Youth (until 23 March 2020)Lily D'Ambrosio, MP Minister for Energy, Environment and Climate Change Minister for Solar Homes Jaala Pulford, MLC Minister for Roads Minister for Road Safety and the TAC Minister for Fishing and Boating Luke Donnellan, MP Minister for Child Protection Minister for Disability, Ageing and Carers Ben Carroll, MP Minister for Crime Prevention Minister for Corrections Minister for Youth Justice (Victoria)