Senff is a German surname.
People with the surname include: Bartholf Senff (1815–1900), German music publisher Birgit Senff, retired German gymnast Carl Adolf Senff (1785-1863), German painter Karl August Senff (1770–1838), Baltic German painter Nida Senff (1920–1995), Dutch swimmer Theresa Senff (b. 1982), German road cyclist