Guzzo () is an Italian surname. Notable people with the surname include:
Alberto Breccia Guzzo (1946–2014), Uruguayan politician and lawyer Garry Guzzo (born 1941), Canadian politician Giovanni Guzzo (born 1986), Venezuelan violinist José Roberto Guzzo (1943–2025), Brazilian journalist Lou Guzzo (1919–2013), American journalist, author and television commentator Marco Guzzo (born 1994), Italian footballer Patsy Guzzo (1914–1993), Canadian ice hockey player, Olympic gold medalist Raphael Guzzo (born 1995), Portuguese footballer Vincenzo Guzzo (born 1969), Canadian entrepreneur