His Sister's Children is a 1911 American silent black and white comedy film produced by Vitagraph Company of America and distributed by General Film Company.

Cast Dolores Costello as Buster aka Budge - One of the Children Helen Costello as Boxer aka Toodle - One of the Children John Bunny Maurice Costello as Harry Burton - the Children's Uncle Rose E. Tapley as Helen Manton - Harry's Sweetheart Tefft Johnson as Harry's Sister's Husband Miss E. Dominicus as Harry's Sister

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