John Hume (1743–1818) was a Dean of the Church of Ireland.

He was born in Oxford and educated at Christ Church, Oxford, getting a BA in 1765 and a MA in 1769. He held livings at Gillingham, Dorset and West Lavington, Wiltshire. He was Dean of Derry from 1783 until his death."Fasti Ecclesiae Hibernicae: The succession of the prelates Volume 3" Cotton, H. pp344/5 Dublin, Hodges & Smith, 1848–1878

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