A handshake is a one-on-one, interpersonal greeting ritual.
Handshake may also refer to:
Handshake (company), an American employment company Handshake (computing), computer terms related to a signal between multiple computing devices or programs Handshake deal, another term for an oral contract Handshaking lemma, a specific statement in graph theory
See also Hand Shakers, a Japanese anime television series Secret Handshake (disambiguation)