Prellwitz is a surname of Prussian origin. Notable people with the surname include:
Edith Mitchill Prellwitz (1865–1944), American artist Henry Prellwitz (1865–1940), American artist Karin von Prellwitz, cofounder of Eulama literary agency
See also Przelewice, Wałcz County, a village in northwestern Poland whose German name is Prellwitz Prillwitz, a village in Germany