Grippo is a surname. Notable people with the surname include:

Angela Grippo, American neuroscientist Carlo Grippo (born 1955), Italian middle distance runner Charles Grippo, American playwright, author and producer Diego Lo Grippo (born 1978), Argentine-Italian basketball player Simone Grippo (born 1988), Swiss footballer Víctor Grippo (1936–2002), Argentine painter

See also Grippo's, snack-food manufacturer Grippa, surname