Amoedo or Amoêdo is a surname. Notable people with the surname include:
Claudio Amoedo (1830–1871), Argentine physician Felipe Amoedo (1828–1900), Argentine politician Guillermo Amoedo (born 1983), Uruguayan film director and screenwriter João Amoêdo (born 1962), Brazilian banker, engineer and company administrator Rodolfo Amoedo (1857–1941), Brazilian painter, designer and decorator Sinforoso Amoedo (1823–1871), Argentine physician