Anne Klein or Ann Klein may refer to:

Ann Klein (1923–1986), American politician Anne C. Klein (born 1947), professor of religious studies Anne Klein (fashion designer) or Hannah Golofsky (1923–1974), American fashion designer and businesswoman Anne Klein (politician) (1950–2011), German lawyer and politician Anne Sceia Klein, American businesswoman and communications specialist

See also Annie Kline, mining pioneer Anna Klein (disambiguation)