James Simms may refer to:
James Simms (instrument maker) (1828–1915), British instrument maker James Simms (Newfoundland official) (1779–1863), lawyer and merchant in Newfoundland James M. Simms (1823–?), African-American minister, newspaper publisher and member of the Georgia Assembly James P. Simms (1837–1887), Confederate States Army general and member of the Georgia legislature
See also James Sims (disambiguation)