Escamilla is a Mexican surname. Notable people with the surname include:
Cuitlahuac Condado Escamilla (born 1978), Mexican politician David Escamilla, harsh vocalist of American metalcore band Crown the Empire Dolores Guadalupe García Escamilla (c. 1966–2005), Mexican crime reporter and anchorwoman Franco Escamilla (born 1981), Mexican comedian, voice actor, musician, philanthropist, businessman, and freestyler Ignacio Escamilla (born 1967), Mexican swimmer Itzan Escamilla (born 1997), Spanish actor Jesus "Jose" Escamilla (1951–2018), American singer-songwriter and filmmaker Jose Escamilla, the first to film rods as alien life forms José María Cañas Escamilla (1809—1860), Salvadoran military figure Juan Carlos Escamilla (born 1978), American politician Kevin Escamilla (born 1994), Mexican footballer Licho Escamilla (1982−2015), American convicted murderer Luis Tristán de Escamilla (c.1585–1624), Spanish painter Luz Escamilla (born 1978), Mexican politician Manuela Escamilla (1648–1721), Spanish playwright, stage actress, and theatre manager Moisés Escamilla May, former leader of the "Old School Zetas" Nicolasa Escamilla (fl. 1747 – fl. 1776), Spanish bullfighter Quique Escamilla (born 1980), Mexican Mayan-Zapotec multi-instrumentalist musician, singer-songwriter, and producer Rosa Luz Alegría Escamilla (born 1949), Mexican physicist and the first woman to serve in the Mexican Executive Cabinet Raymundo Escamilla (born 1964), Mexican politician Teo Escamilla (1940–1997), Spanish cinematographer
See also Rafael Perez-Escamilla, Mexican-American public health nutritionist