Křížek (feminine Křížková) is a Czech surname. Notable people with the surname include:
Erin Krizek, American military officer Matthias Krizek (born 1988), Austrian cyclist Milan Křížek (1926–2018), Czech composer, music teacher and viola player Paul Krizek (born 1961), American politician Zdeněk Křížek (born 1983), Czech footballer