Brassington is an English surname. Notable people with the surname include:
Andrew Brassington (born 1954), English cricketer Christian Brassington (born 1983), English actor Isaac Brassington (1870–1932), British trade unionist and activist Pat Brassington (born 1942), Australian artist Phil Brassington (born 1970), Australian baseball player Samuel Brassington (1901–1950), Australian politician William Brassington (1837/1841 – 1905), New Zealand stonemason, sculptor and builder