Plasencia is a surname. Notable people with the surname include:
(born 1974), German journalist (1837–1903), Spanish politician and soldier Casto Plasencia (1846–1890), Spanish painter César Plasencia, American soccer player Félix Plasencia, Venezuelan politician and diplomat Jorge A. Plasencia (born 1974), American businessman Juan de Plasencia (1520–1590), Spanish friar (born 1943), Spanish footballer Nestor Plasencia (born c. 1950), tobacco grower and cigar maker Rene Plasencia (born 1973), American politician Steve Plasencia (born 1956), American long-distance runner Susan Plasencia, American politician (1809–1893), Spanish composer (c. 1809–1894), Spanish composer (born 1976), Peruvian politician (born 1961), Peruvian prelate Manuela Villarán de Plasencia (1840–1888), Peruvian poet and journalist