Dupee is a surname. Notable people with the surname include:
Caroline Dupee Wade (1857–1947), American painter Dave Dupee (1916–2008), American professional basketball player F. W. Dupee (1904–1979), American literary critic Frank Dupee (1877–1956), American baseball player George Washington Dupee (1826–1897), American slave-turned-Baptist leader Kenneth Dupee Swan (1887–1970), American photographer Leonard Dupee White (1891–1958), American historian Michael George Dupée (born 1966), American game show contestant and author