Brandegee is a surname. Notable people with the surname include:
Augustus Brandegee (1828–1904), American lawyer and politician Frank B. Brandegee (1864–1924), American politician Mary Katharine Brandegee (1844–1920), American botanist Townshend Stith Brandegee (1843–1925), American botanist
See also Brandegee Estate, a historic estate in Massachusetts