Dufau is a French surname. Notable people with the surname include:
André Dufau (1905–1990), French sprinter Clémentine-Hélène Dufau (1869–1937), French artist Jean-Pierre Dufau (born 1943), French politician Jenny Dufau (1878–1924), French opera singer Julien Dufau (1888–1916), French rugby union player Loïc Dufau (born 1989), French footballer Pierre Dufau (1908–1985), French architect