Mesophysa is a genus of small-headed flies endemic to eastern Australia. It has been treated as a synonym of Panops by some authors, and a separate genus by others. Males and females measure 8–10 mm and 9–11 mm, respectively.

Species Mesophysa flavipes (Latreille, 1811) Mesophysa ilzei Neboiss, 1971 Mesophysa tenaria Neboiss, 1971 Mesophysa ultima Neboiss, 1971

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