Safadi or al-Safadi is an Arabic surname (nisba) which denotes an origin from the city of Safed (also Safad/Zefat). Safdie is a Sephardic kaneani surname of the same origin.

Notable people with the name include: Al-Safadi, Mamluk author and historian Al-Khalidi al-Safadi, Ottoman historian and mufti Ayman Safadi, Jordanian politician Bassel Safadi, Palestinian-Syrian Software engineer Benny Safdie, American film director, one-half of the Safdie brothers Dalal Khalil Safadi, Lebanese writer Joe Safdie, American poet Josh Safdie, American film director, one-half of the Safdie brothers Mohammad Safadi, Lebanese businessman and politician Moshe Safdie, Israeli-Canadian-American architect Nicasio Safadi, Ecuadorian musician of Lebanese descent Omar Al-Safadi, Qatari handball player Oren Safdie, playwright and screenwriter, son of Moshe Safdie brothers, American film directors Shaddy Safadi, American video game artist Sylvia Safdie, Canadian artist Tala Safadi, Israeli-Arab beauty queen Violette Khairallah Safadi, Lebanese politician Yami Safdie, Argentine singer