Mignanelli is a surname. Notable people with the surname include:
Bertrando de Mignanelli ((1370–1455 or 1460), Italian merchant Daniele Mignanelli (born 1993), Italian footballer Fabio Mignanelli (d. 1557), Italian Roman Catholic bishop Giacomo Mignanelli (d. 1576), Italian Roman Catholic prelate Matt Mignanelli (born 1983), American artist