Polwhele is a surname. Notable people with the surname include:
John Polwhele Blatchley (1913–2008), London-born car designer known for his work with J Gurney Nutting and Rolls-Royce Elizabeth Polwhele (1651–1691), playwright, one of the first women to write for the professional stage in London Richard Polwhele (1760–1838), Cornish clergyman, poet and historian of Cornwall and Devon Theophilus Polwhele (died 1689), English ejected minister
See also Powel (disambiguation) Powle