The 2018 Midwestern State Mustangs football team represented Midwestern State University in the 2018 NCAA Division II football season. They were led by head coach Bill Maskill, who is in his 17th season at Midwestern State. The Mustangs played their home games at Memorial Stadium and were members of the Lone Star Conference.
Schedule Midwestern State announced its 2018 football schedule on April 13, 2018. The schedule consisted of six home and four away games in the regular season. The Mustangs hosted LSC foes Angelo State, Texas A&M–Commerce, West Texas A&M, and Tarleton State and traveled to UT Permian Basin, Eastern New Mexico, Texas A&M–Kingsville, and Western New Mexico.
The Mustangs hosted two non-conference games against Humboldt State from the Great Northwest Athletic Conference and West Florida from the Gulf South Conference, who were the national runners-up in 2017."Midwestern State Mustangs 2018 football schedule" Times Record News. Retrieved 2018-09-02.
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