Vlachopoulos (), feminine: Vlachopoulou () is a Greek surname. Notable people include:
Alexakis Vlachopoulos (1780–1865), Greek military leader, brother of Konstantinos Angelos Vlachopoulos (born 1991), Greek water polo player Aristotelis Vlachopoulos (1866–1960), Greek Army general Konstantinos Vlachopoulos (1789–1868), Greek military leader, brother of Alexakis Nikolaos Vlachopoulos (1868–1957), Greek Army general Orestes Vlachopoulos (1921–1984), Greek industrialist Rena Vlachopoulou (1917–2004), Greek actress Vassilis Vlachopoulos (1883–1944), Greek Army general and politician, great-grandson of Alexakis Vlachopoulos