Mitarai (written: 御手洗) is a Japanese surname. The rough translation is "a place for a purification ceremony with water at the entrance to shrines and temples".

Notable people with the surname include:

, Japanese businessman , Japanese murder victim , Japanese businessman

Fictional Characters: Ryota Mitarai (御手洗 亮太|) A Character from Danganronpa 3: The End of Hope's Peak High School Shota Mitarai, a character in The Idolmaster 2 and The Idolmaster SideM Susugu Mitarai, a character in My Hero Academia

Other uses Mitarai Dam, a rockfill dam in Kagoshima Prefecture Mitarai, a coastal town on Osaki Shimojima Island in the Seto Inland Sea. Mitarai valley, a mountain valley in the Yoshino-Kumano National Park, Kansai region