Penka may refer to:
Proenkephalin, or PENKA, endogenous opioid polypeptide hormone Karl Penka (1847–1912), Austrian philologist and anthropologist Penka Kouneva (born 1967), Bulgarian-American composer Penka Metodieva (born 1950), Bulgarian basketball player Penka Sokolova (1946–1977), Bulgarian hurdler Penka Stoyanova (born 1950), Bulgarian basketball player Vela Peeva (1922–1944), Bulgarian communist partisan also known as Penka
See also Panka Pelishek (1899–1990), Bulgarian pianist and music teacher