Mendiola is a surname. Notable people with the surname include:
Benigna Mendiola (born 1944), Nicaraguan socialist, revolutionary, and peasant leader Christopher Mendiola (born 1990), Guam footballer Dennis Mendiola (businessman), American investment banker and chief executive Dennis C. Mendiola, Northern Mariana Islander politician Jessy Mendiola (born 1992), Filipino actress Jim Mendiola, American screenwriter and film director Joseph M. Mendiola, Northern Mariana Islands politician Raúl Mendiola (born 1994), Mexican footballer