Cuenco is a surname. Notable people with the surname include:
Cuenco family Antonio Cuenco (born 1936), Filipino politician Ernani Cuenco (1936–1988), Filipino composer José María Cuenco (1885–1972), Filipino Archbishop Juliet Cuenco, Filipino-Canadian rights activist Mariano Jesús Cuenco (1888–1964), Filipino politician and writer Monica Cuenco (born 1994), Filipino singers Rey Cuenco (1960–1996), Filipino basketball player