Ghodsi (, literally "sacred", "sacramental"; transcription from the Persian script of the adjective form of Ghods/Quds (), the corresponding transliteration from the Arabic script being Qudsi (lit.: Jerusalemite, someone whose family originated from Jerusalem) is a Persian surname.
Notable people with the surname include:
Ali Ghodsi, Swedish-Iranian computer scientist Gholamreza Ghodsi (1925–1989), Iranian belletrist and poet Mohammad Ghodsi, Iranian computer scientist and electrical engineer