para-Aminoblebbistatin is a water-soluble, non-fluorescent, photostable myosin II inhibitor, developed from blebbistatin. Among the several blebbistatin derivatives it is one of the most promising for research applications. Furthermore, it has a favourable overall profile considering inhibitory properties and ADME calculations.
Myosin specificity SpeciesMyosin typeIC50RabbitSkeletal muscle myosin S11.3 μM, 9.22 μM, 0.98 μMin press: Dictyostelium discoideumMyosin II motor domain6.6 μM, 8.5 μMHumanslow-twitch skeletal muscle fibre (force)10 μMPig (left ventricle)cardiac myosin5.3 μMChicken (gizzard)smooth muscle myosin S113 μMHuman (expressed in Sf9 cells)non-muscle myosin 2A / B / C motor domains9 / 20 / 7.2 μMDrosophila melanogasterbodywall muscle fiber8.5 μM
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