Tweedy is a Scottish surname. Notable people with the surname include:
Alfred Tweedy (born 1880), American politician Alice B. Tweedy (1850–1934), American journalist and writer Cheryl Tweedy (born 1983), English singer, dancer, and television personality Damon Tweedy, American physician and academic Frank Tweedy (1854–1937), American botanist George Tweedy (1913–1987), English footballer Hilda Tweedy (1911–2005), Irish women's rights activist Jeff Tweedy (born 1967), American songwriter, musician, and record producer John Tweedy (1849–1924), British surgeon John Hubbard Tweedy (1814–1891), American politician Samuel Tweedy (1776–1868), American politician