Perna is a surname. Notable people with the surname include:
Armando Perna (born 1981), Italian football central defender Gustave F. Perna (born 1960), United States Army general Martín Perna (born 1975), American educator and artist Pietro Perna (1519–1582), Italian printer Rosalba Perna, Italian-American astrophysicist William Perna, American filmmaker