Hassanein () is an Arabic surname. Notable people with the name include:
Ali Hassanein or Ali Hussnein Ali Sadiq Hussnein, (1925–2018), Libyan politician Ali Hassanein (actor) (1939–2015), Egyptian actor Ahmed Hassanein Pasha (1889–1946), or Aḥmad Moḥammad Makhlūf Ḥasanēn al-Būlākī, Egyptian courtier, diplomat, Olympic athlete in fencing, photographer, writer, politician and explorer, tutor then chamberlain to King Farouk Ahmed Hassanein (American football) (born 2002), American-Egyptian football player Hassan Hassanein (1916–1957), Egyptian golfer Mohamed Hassanein Heikal (1923–2016), Egyptian journalist Mohamed Hassanein (born 1913), Egyptian swimmer Muhammad Hassanein, Egyptian politician and government minister Mustafa Hassanein aka Mustafa Mohammad (born 1968), IFBB professional bodybuilder Rami Hassanein (1975-2016), Egyptian officer