The University of Pennsylvania Health System (UPHS) is a major multi-hospital health system headquartered in Philadelphia, Pennsylvania. UPHS and the Perelman School of Medicine at the University of Pennsylvania together comprise Penn Medicine, a clinical and research entity of the University of Pennsylvania. UPHS hospitals include the Hospital of the University of Pennsylvania, Penn Presbyterian Medical Center, Pennsylvania Hospital, Chester County Hospital, Lancaster General Hospital, Princeton Medical Center, and Doylestown Hospital.
The UPHS is home to the first hospital in the United States, Pennsylvania Hospital.
History
The Chester County Hospital and Health System joined UPHS in 2013. Two years later, Lancaster General Health (LG Health) joined the UPHS family. Princeton Health officially merged into UPHS in January 2018. UPHS added Doylestown Hospital as its seventh hospital in 2025.
Phoenixville Hospital in Phoenixville, Pennsylvania, was previously part of the UPHS network but was sold to Community Health Systems in 2004. Phoenixville Hospital was sold again by CHS to Tower Health in 2017.
In 2020, University of Pennsylvania-Penn Presbyterian was ranked as the 15th best hospital in the United States by the U.S. News & World Report.
Major facilities Facility Location Type of facility Year opened Year joined UPHS Notes Hospital of the University of Pennsylvania University City, Philadelphia, Pennsylvania Teaching 1874 1993 First university-owned teaching hospital in the United States Pennsylvania Hospital Center City, Philadelphia Teaching 1751 1993 First hospital of the United States Penn Presbyterian Medical Center University City, Philadelphia Teaching 1871 1995 Houses Penn's departments of Orthopaedics and Ophthalmology, in addition to long-term care and nursing home facilities Chester County Hospital West Chester, PA Teaching 1892 2013 Lancaster General Hospital Lancaster, PA Teaching 1893 2015 Part of the Penn Medicine Lancaster General Health network Princeton Medical Center Plainsboro Township, NJ Teaching 1919 2018 Part of the Penn Medicine Princeton Health network Doylestown Hospital Doylestown, PA Teaching 1923 2025 Part of Penn Medicine Doylestown Health network. Perelman Center for Advanced Medicine University City, Philadelphia Specialist 2008 2008 Houses the Abramson Cancer Center and Roberts Proton Therapy Center Penn Medicine University City University City, Philadelphia Specialist Home to the Penn Musculoskeletal Center Penn Medicine Rittenhouse Southwest Center City, Philadelphia Rehabilitation 1916 1997 Houses the Penn Medicine Institute for Rehabilitation Medicine (operated by Good Shepherd Penn Partners) and the Specialty Hospital at Rittenhouse Penn Medicine Radnor Radnor Township, PA Outpatient Comprehensive primary and specialized outpatient care. Penn Medicine Cherry Hill Cherry Hill, NJ Outpatient Women & Babies Hospital Lancaster, PA Specialist 2000 2015 Specialty hospital for babies and women of all ages, part of the Lancaster General Health network Lancaster Rehabilitation Hospital Lancaster, PA Rehabilitation 2007 2015 Part of the Penn Medicine Lancaster General Health network, co-owned by Kindred Healthcare Lancaster Behavioral Health Hospital Lancaster, PA Psychiatric hospital Part of the Penn Medicine Lancaster General Health network, co-owned by Universal Health Services
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