Chiara Fancelli (died 21 May 1541) was a figure in Florentine history, best known as the daughter of the architect Luca Fancelli and the wife and model of Pietro Perugino.

Her precise birth date and birthplace are unknown. She married Perugino on 1 September 1493, bringing a dowry of five hundred gold florins. She had three sons and two daughters with him Piero Bargellini, La soave mestizia del Perugino, p. 255, 1950 and was the model for his Madonnas from 1494 onwards. Eugène Müntz, Histoire de l'art pendant la renaissance: Italie; l'âge d'or, 1891. On 6 October 1524, after her husband's death, she wrote to Isabella d'Este to offer her his Mars and Venus Surprised by Vulcan for her studiolo, but d'Este refused it.Stephen John Campbell, The cabinet of eros: Renaissance mythological painting and the studiolo of Isabelle d'Este, p. 175, 2004 She was buried in the cloister of the dead at Santissima Annunziata, Florence.

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