Osofsky is a surname. Notable people with the surname include:
Aileen Osofsky (1926–2010), American community leader, philanthropist, and bridge player Barbara L. Osofsky (born 1937), American mathematician Howard Osofsky (born 1935), American gynecologist, obstetrician, and psychiatrist, husband of Joy Joy Osofsky, American psychologist, wife of Howard Lisa Osofsky (born 1961), American-British lawyer Steven Osofsky, American veterinarian See also Ossowski